Table III.

Crude and adjusted ORs and 95% CIs for promoter methylation of the MAL, KIF1A, FKBP4 and OGDHL genes in breast cancer cases and controls.

Gene	BC cases	Controls	Crude OR (95% CI)	P-value	Adjusted ORa (95% CI)	P-value	Adjusted ORb (95% CI)	P-value
MAL
Methylated	16	4	44 (4.3–448.6)	<0.001c	46.3 (3.9–550.3)	0.002c	83 (2.8–2422.7)	0.01c
Not methylated	1	11
KIF1A
Methylated	3	2	1.6 (0.2–10.8)	>0.999	1.8 (0.3–12.7)	0.564	21 (0.5–819.6)	0.104
Not methylated	16	17
FKBP4
Methylated	4	1	4.8 (0.5–47.7)	0.340	4.2 (0.4–43.0)	0.229	5.9 (0.3–130.1)	0.258
Not methylated	15	18
OGDHL
Methylated	4	0	7.0d (1.56e-60–3.15e+61)	0.978	6.7d (1.24e-60–3.62e+61)	0.979	6.5d (8.61e-61–4.94e+61)	0.979
Not methylated	15	19

^aAdjusted by age and family history of breast cancer;

^badjusted by age, family history of breast cancer and DRC.

^cStatistically significant results.

^dOnly cases are methylated, thus GLM was used to estimate odds, risk, by exponentiation of the appropriate coefficients.

BC, breast cancer; OR, odds ratio; CI, confidence interval.