Table 2.
Latency (in seconds) to attack bite, frequency of aggressive and duration (in seconds) of nonaggressive behaviors after microinjection of vehicle or F15599 (5-HT1A receptor agonist, in different doses), in the infralimbic (IL) cortex
| Behavior | Vehicle |
F15599 doses (μg/0.2 μl)
|
|
|---|---|---|---|
| 0.2 μl (n=6) | 0.1 (n=4) | 1.0 (n=6) | |
| Latency | |||
| First attack bite (s) | 12.2+1.3 | 7.5+1.7 | 13.0+2.3 |
| Frequency of aggressive elements | |||
| Attack bites | 21.2+3.4 | 26.3+3.0 | 16.7+3.6 |
| Sideways threat | 18.8+1.4 | 25.4+4.1 | 15.5+3.8 |
| Pursuit | 2.2+1.4 | 1.3+0.8 | 0.8+0.5 |
| Sniff | 6.3+1.6 | 8.3+1.4 | 6.0+1.1 |
| Tail rattle | 16.5+2.9 | 18.8+3.1 | 19.5+2.7 |
| Duration of nonaggressive elements | |||
| Walk (s) | 61.5+11.4 | 77.5+14.8 | 59.7+3.3 |
| Groom (s) | 20.2+6.7 | 27.5+14.7 | 23.8+7.9 |
| Rear (s) | 15.0+4.9 | 11.5+3.5 | 10.0+3.3 |
Data expressed in mean ± SEM