Skip to main content
. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Arthritis Rheum. 2013 Feb;65(2):408–417. doi: 10.1002/art.37768

Figure 1.

Figure 1

Influence of hedgehog proteins on superficial zone protein (SZP) accumulation in surface zone articular chondrocytes. Primary cells were cultured for 4 days as monolayers in serum-free chemically defined medium with graded levels (0.1, 0.3 and 1µg/ml) of Sonic hedgehog (Shh) and Indian hedgehog (Ihh). SZP accumulation in spent medium was quantified according to enzyme-linked immunosorbent assay. Both Shh and Ihh stimulated the SZP accumulation significantly at all concentration. Values are the mean ± standard deviations, with n=6 (*p<0.01 compared with the value of the control cultures).