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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Arthritis Rheum. 2013 Feb;65(2):408–417. doi: 10.1002/art.37768

Figure 5.

Figure 5

Increased superficial zone protein (SZP) accumulation by inhibition of Wnt/β-catenin pathway. Primary cells were cultured for 4 days as monolayers in serum-free chemically defined medium with antagonist of LRP5/6 co-receptor; Sclerostin (SOST) or Dickkopf-1 (DKK-1). SZP accumulation in spent medium was quantified according to enzyme-linked immunosorbent assay. Both SOST (1 and 3 µg/ml) and DKK-1 (0.1, 0.3 and 1 µg/ml) significantly stimulated SZP accumulation. Values are the mean ± standard deviations, with n=6 (*p<0.01 and **p<0.05, compared with the value of the control cultures).