Table 3.
Influence of Bile Salt Structure [micelle vs. nonmicelle (TDHC); conjugated (TC) vs. unconjugated (NC) on Their Choleretic Potential (μL of bile per μmole of bile salt)]
| Species | TC | NC | UDC | Nor-UDC | TDHC |
|---|---|---|---|---|---|
| Rat | 8.4–15 (285,438) | 10 (416) | ~40 (282) | 91 (416) | 30–40 (81) |
| Rabbit | 9 (474) | – | – | – | |
| Guinea Pig | 20–30 (599) | – | ~22 (599) | ~31 (599) | – |
| Hamster | ~ 10 (204) | – | ~23 (599) | ~ 67 (599) | – |
| Dog | 8 (417,586) | – | – | 15 (417) | – |
| Cat | 7.9 (492) | – | – | – | – |
| Rhesus monkey | 13–20(36,145) | – | – | – | 60–78 (36) |
| Baboon | 10–22 (527) | – | – | – | – |
| Human | 6.7 (80) | – | – | – | 17.3 (80) |
NOTE: Numbers in parentheses are references.
Data are estimated from studies in different species (Modified from (76) with permission).
Abbreviations: TC, taurocholate; NC, nor-cholate; UDC, ursodeoxycholate; Nor-UDC, nor-ursodeoxychoalte; TDHC, taurodehydrocholate.