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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Inflamm Bowel Dis. 2014 May;20(5):811–820. doi: 10.1097/MIB.0000000000000022

FIGURE 4.

FIGURE 4

DSS treatment induces the expression of Klf4 in the colonic crypts proliferative zone. Immunofluoroscence staining of Klf4 in the colonic epithelium. A and B, Expression of Klf4 in the normal colonic epithelium of untreated Klf4fl/fl mice is limited to the nonproliferating differentiated cells in the upper half of the colonic crypts. C and D, Klf4 expression is extended into the proliferative zone (arrows) of Klf4fl/fl mice after DSS treatment. E and F, Absence of Klf4 staining in the colonic epithelium of Klf4ΔIS mice.