Figure 1. Helminth co-infection exacerbates C. rodentium-induced colitis and mortality in MyD88 KO mice.

MyD88 knockout and wild-type C57BL/6 mice were infected with H. polygyrus (200 L3) and inoculated with C. rodentium (5×10⁸ CFU) 7 days later. A & C: Body weight changes of wild-type (A) and MyD88 knockout (C) mice that were infected with C. rodentium, H. polygyrus, both H. polygyrus and C. rodentium, and normal control mice during the course of the experiment (8 days) are shown. Data shown are pooled from three independent experiments and are expressed as the body weight change as a percentage of the individual mouse initial body weight ± SE (n = 10–15) at each time point. B &D: Survival curve in wild-type (B) and MyD88 knockout (D) mice. H. polygyrus co-infection results in a significantly increased mortality in MyD88 KO mice.