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Structure and functional domains of A20. The ovarian tumor (OTU) domain (red) and seven zinc fingers (Zfs) are shown. The cystine 103 and Zf4 motifs implicated in ubiquitin-modifying activity are indicated in yellow. Orange circles point to ubiquitin-binding motifs. A20 interacts with multiple other proteins, including other ubiquitin-binding proteins, ubiquitin-modifying enzymes, and kinases.
