Table IV.
Viability of HIFF cells treated with flavonols.
| A, Viability of cells treated with 50 μM flavonol | |||
|---|---|---|---|
|
| |||
| Flavonol | N | % Viability of HIFF (50 μM)a | |
| Quercetin | 3 | 84.47±2.21% | |
| Kaempferol | 3 | 73.82±1.38% | |
| Kaempferide | 3 | 52.17±1.17% | |
| Galangin (5f) | 3 | 47.95±1.38% | |
| 3′-Iodo flavonol (5c) | 4 | 46.79±2.48% | |
| 4′-Iodo flavonol (5d) | 3 | 34.77±0.99% | |
| 4′-Methyl flavonol (5e) | 3 | 37.50±2.27% | |
| 3′-Benzoyl flavonol (5a) | 3 | 34.80±0.20% | |
| 3′-Phenyl flavonol (8c) | 3 | 34.63±2.74% | |
| 4′-Phenyl flavonol (8d) | 5 | 34.42±3.67% | |
| 4′-Benzoyl flavonol (5b) | 3 | 32.33±2.92% | |
|
| |||
| B, Viability at the average combined EC50 concentration of DU-145 and PC-3 for each flavonol | |||
|
| |||
| Flavonol | N | Flavonol (μM) | % Viability of HIFFa |
|
| |||
| 4′-Benzoyl flavonol (5b) | 3 | 13 | 110.92±3.20% |
| 3′-Iodo flavonol (5c) | 4 | 13 | 105.98±5.79% |
| Kaempferol | 4 | 36 | 105.57±5.66% |
| Quercetin | 6 | 36 | 94.01±7.67% |
| Galangin (5f) | 4 | 20 | 92.63±5.58% |
| 3′-Benzoyl flavonol (5a) | 6 | 12 | 90.36±4.85% |
| Kaempferide | 3 | 17 | 83.91±1.31% |
| 4′-Phenyl flavonol (8d) | 4 | 6 | 82.09±5.48% |
| 4′-Iodo flavonol (5d) | 3 | 6 | 70.21±2.70% |
| 4′-Methyl flavonol (5e) | 3 | 12 | 65.00±4.12% |
| 3′-Phenyl flavonol (8c) | 3 | 6 | 53.08±9.54% |
a
Values are mean ± SEM.