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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Bone. 2014 May 15;65:83–91. doi: 10.1016/j.bone.2014.05.006

Table 1.

Dynamic histomorphometry of varying age cortical bone subjected to two different tibial compression loading magnitudes

Outcomes −2200 με −3000 με
5 mo (n=12) 12 mo (n=11) 22 mo (n=11) 5 mo (n=11) 12 mo (n=13) 22 mo (n=12)
Control Loaded Control Loaded Control Loaded Control Loaded Control Loaded Control Loaded
Ps.sLS/BS [%] 10 ± 9 28 ± 15* 4 ± 6 45 ± 29* 2 ± 2 41 ± 21* 27 ± 20 16 ± 11 21 ± 18c 25 ± 13 13 ± 14 37 ± 16*
Ps.dLS/BS [%] 0 ± 1 54 ± 24* 0 ± 1 18 ± 20*a 0 ± 0 12 ± 19a 0 ± 0 48 ± 18* 0 ± 0 61 ± 14* 0 ± 0 41 ± 19*b
Ps.MS/BS+ [%] 6 ± 6 69 ± 17* 3 ± 4 40 ± 25* 1 ± 1a 33 ± 20*a 14 ± 10 77 ± 13* 11 ± 9c 78 ± 8* 8 ± 7 61 ± 16*b
Ps.MAR+ [μm/d] 1.2 ± NA 2.1 ± 0.4 1.2 ± NA 1.3 ± 0.2a NA 1.4 ± 0.4a 1.3 ± 0.5 6.5 ± 3.9* 0.7 ± NA 2.8 ± 1.4a 1.1 ± 0.1 2.3 ± 1.0a
Ps.BFR/BS+ [μm/d] 0.21 ± NA 1.51 ± 0.63* 0.15 ± NA 0.70 ± 0.35a NA 0.54 ± 0.42a 0.17 ± 0.17 4.9 ± 2.6* 0.12 ± NA 2.3 ± 1.2a 0.05 ± 0.01 1.5 ± 1.0a
Ps.Wo.S/BS [%] 0 ± 0 3 ± 9 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0 21 ± 16* 0 ± 0 5 ± 8* 0 ± 0 1 ± 2
Ps.Woven Area [mm2] NA 0.04 ± 0.05 NA NA NA NA NA 0.12 ± 0.09 NA 0.05 ± 0.04 NA 0.05 ± 0.04
Ps.Incidence of Woven 0 3 0 0 0 0 0 10* 0 6*a 0 2a
Ec.sL/BS [%] 69 ± 26 23 ± 12* 55 ± 19 34 ± 11* 50 ± 12 41 ± 11 54 ± 16 15 ± 8* 42 ± 14 11 ± 5* 56 ± 11 26 ± 15*
Ec.dL/BS [%] 3 ± 3 20 ± 9* 8 ± 6 13 ± 11 7 ± 6 19 ± 12* 5 ± 7 29 ± 12* 5 ± 5 40 ± 14* 6 ± 8 30 ± 12*
Ec.MS/BS+ [%] 37 ± 12 31 ± 11* 35 ± 13 30 ± 13 33 ± 9 40 ± 14 32 ± 8 36 ± 11 26 ± 8a 45 ± 12 34 ± 8b 43 ± 11*
Ec.MAR+ [μm/d] 1.6 ± 0.93 2.0 ± 0.6* 2.1 ± 0.78 2.1 ± 0.8 1.9 ± 1.08 2.6 ± 1.8 2.0 ± 0.7 3.7 ± 0.7* 2.4 ± 1.4 3.8 ± 1.4* 2.1 ± 0.5 3.8 ± 2.4
Ec.BFR/BS+ [μm/d] 0.53 ± 0.23 0.63 ± 0.3* 0.72 ± 0.22 0.60 ± 0.22 0.61 ± 0.31 1.02 ± 0.56 0.65 ± 0.31 1.4 ± 0.6* 0.54 ± 0.16 1.8 ± 1.0* 0.79 ± 0.21 1.7 ± 1.2*
Ec.Wo.S/BS [%] 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0* 0 ± 1 0 ± 0 2 ± 4 0 ± 0 3 ± 5
Ec.Woven Area [mm2] NA NA NA NA NA NA NA 0.01 ± NA NA 0.02 ± 0.01 NA 0.03 ± 0.01
Ec.Incidence of Woven 0 0 0 0 0 0 0 1 0 2 0 3
*

p<0.05, Control vs. Loaded

a

: significant difference compared to 5 month of respective load

b

: significant difference compared to 12 month of respective load

c

: significant difference compared to −2200 με (Control) , p<0.05.

NA: No samples with a non-zero value

Value ±NA: less than three samples with a non-zero value

Data are represented as mean±SD

MS/BS+, MAR/BS+, BFR/BS+ represent the combination of lamellar and woven values