Fig. 1.

The general model for protein aggregation. A monomer will self-aggregate to form a protofibril. The protofibril can then continue aggregation via two distinct pathways: elongation, where monomer addition continues, or lateral association, where protofibrils join together side-to-side to form fibrils. Inset: fibril growth as a function of time. The characteristic curve of fibril formation includes a lag-phase prior to nucleation, an exponential growth region and the stationary phase.