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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Bioessays. 2013 Mar 1;35(5):430–435. doi: 10.1002/bies.201200163

Figure 2. Regulation of YAP by GPCRs and F-actin.

Figure 2

Although many classes of GPCRs appear capable of promoting YAP activation, those like PAR1 that signal strongly through the Gα12/13 family are especially potent. Gα12/13 recruitment of Rho-GEFs causes RhoA activation and F-actin assembly, which promotes Lats1/Lat2 inactivation by an unknown, but myosin-independent mechanism. The generation of stress fibers, which entails both F-actin and myosin activation, also promotes YAP activation, however independently of Lats1/Lats2 inhibition. Not shown is the ability of some Gαs-linked GPCRs to promote the phosphorylation and inactivation of YAP. Solid and dashed lines and colors are used as in figure 1.