Although many classes of GPCRs appear capable of promoting YAP activation, those like PAR1 that signal strongly through the Gα12/13 family are especially potent. Gα12/13 recruitment of Rho-GEFs causes RhoA activation and F-actin assembly, which promotes Lats1/Lat2 inactivation by an unknown, but myosin-independent mechanism. The generation of stress fibers, which entails both F-actin and myosin activation, also promotes YAP activation, however independently of Lats1/Lats2 inhibition. Not shown is the ability of some Gαs-linked GPCRs to promote the phosphorylation and inactivation of YAP. Solid and dashed lines and colors are used as in figure 1.