Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: J Cardiovasc Pharmacol. 2014 Jul;64(1):87–99. doi: 10.1097/FJC.0000000000000094

Anti-hypertensive effects of 19, 20- EDP and 14, 15- EET in angiotensin-II dependent hypertension. A. Systolic blood pressure (SBP) is shown as percent change from baseline. Blood pressure readings commenced with initiation of Ang II infusion. TPPU was administered in drinking water at a 0.2 mg/kg dose each day for five days before the induction of hypertension by Ang II. B. Marginal group means of days 6–12 are shown. Statistically significant differences (P < 0.05) are indicated with an asterisk as compared to Ang II infused animals. Data are mean ± SEM. Ang II alone, n=6–8; Ang II + 19, 20- EDP, n= 8–9; Ang II + 19, 20- EDP + TPPU (0.2 mg/kg), n=7–9; Ang II + 14, 15- EET + TPPU (0.2 mg/kg), n= 6–8; Ang II + TPPU (0.2 mg/kg), n= 4–6, Ang-II + 19, 20-EDP + TPPU (0.02 mg/kg), n =6, Ang-II + 19, 20-EDP + TPPU (0.06 mg/kg), n =9. The symbol (*) on Panel B indicates P < 0.05 as compared to all other groups. Differences in SBP between Ang II infused animals and other treatment groups are indicated with an asterisk.

Anti-hypertensive effects of 19, 20- EDP and 14, 15- EET in angiotensin-II dependent hypertension. A. Systolic blood pressure (SBP) is shown as percent change from baseline. Blood pressure readings commenced with initiation of Ang II infusion. TPPU was administered in drinking water at a 0.2 mg/kg dose each day for five days before the induction of hypertension by Ang II. B. Marginal group means of days 6–12 are shown. Statistically significant differences (P < 0.05) are indicated with an asterisk as compared to Ang II infused animals. Data are mean ± SEM. Ang II alone, n=6–8; Ang II + 19, 20- EDP, n= 8–9; Ang II + 19, 20- EDP + TPPU (0.2 mg/kg), n=7–9; Ang II + 14, 15- EET + TPPU (0.2 mg/kg), n= 6–8; Ang II + TPPU (0.2 mg/kg), n= 4–6, Ang-II + 19, 20-EDP + TPPU (0.02 mg/kg), n =6, Ang-II + 19, 20-EDP + TPPU (0.06 mg/kg), n =9. The symbol (*) on Panel B indicates P < 0.05 as compared to all other groups. Differences in SBP between Ang II infused animals and other treatment groups are indicated with an asterisk.