TABLE 1.
Plasma concentration and tissue level of the sEH inhibitor TPPU.
| [TPPU]plasma (nmol/L) | [TPPU]kidney (nmol/g tissue) | ||||
|---|---|---|---|---|---|
|
| |||||
| n | Day 71 | Day 14 | P value (day 7 vs. 14) | Day 14 | |
| Ang II + TPPU | 5 | 630 ± 60 | 800 ± 50 | 0.09 | 1.3 ± 0.1 |
| Ang II + 19, 20-EDP + TPPU | 5 | 680 ± 60 | 850 ± 90 | 0.08 | 1.3 ± 0.1 |
| Ang II + 14,15-EET + TPPU | 5 | 670 ± 70 | 680 ± 90 | 0.8 | 1.1 ± 0.1 |
1
Time after ANG II infusion started. Data are mean ± SEM. The water intake of animals was in average of 5 ± 1, 4.9 ± 0.8 and 5.1 ± 0.7 ml/day in animals treated with Ang II + TPPU, Ang II + 19, 20- EDP + TPPU and Ang II + 14, 15- EET + TPPU for the duration of the experiment. See Table S12 for TPPU concentrations in the drinking water.