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Clinical and laboratory criteria for the systemic inflammatory response syndrome (SIRS). Note: Patients must present with at least two of the following and *must include either 1 or 4
| 1. *Temperature > 38° C or < 36° C (as determined by central temperature) |
| 2. Heart rate > 90th percentile for age |
| 3. Respiratory rate >90th percentile for age, or hyperventilation to PaCO2 < 32 torr |
| 4. *White blood cell count >12,000 cells/mm3, or <4,000 cells/mm3 |
