Table 3.

Gender-specific risk of dementia and Alzheimer disease, conditional on survival free of dementia or AD to age 65. Framingham Heart Study, Original and Offspring cohorts, 1975-2009.

	# events		Competing Mortality- Unadjusted cumulative incidence (CM-UCI)†		P*	Competing Mortality- Adjusted cumulative incidence (CM-UCI)‡		P*
	Women	Men	Women	Men		Women	Men
Dementia
10 year risk	44	47	2.1 (1.5-2.7)	2.9 (2.1-3.7)	0.13	1.9 (1.4-2.5)	2.5 (1.8-3.2)	0.23
20 year risk	263	159	16.3 (14.4-18.1)	14.6 (12.4-16.8)	0.26	11.7 (10.4-13.0)	8.7 (7.4-10.0)	0.002
30 year risk	474	253	44.1 (40.4-47.9)	49.1 (41.9-56.3)	0.23	22.4 (20.6-24.2)	14.9 (13.2-16.6)	<0.001
Lifetime risk	503	259	76.5 (60.8-92.1)	60.7 (50.0-71.4)	0.10	24.6 (22.7-24.5)	15.5 (13.7-17.2)	<0.001
AD
10 year risk	33	25	1.6 (1.1-2.1)	1.5 (0.9-2.1)	0.90	1.5 (1.0-2.0)	1.3 (0.8-1.8)	0.72
20 year risk	209	104	13.2 (11.5-14.9)	10.2 (8.2-12.1)	0.02	9.4 (8.2-10.6)	5.9 (4.8-7.0)	<0.001
30 year risk	384	173	37.8 (34.0-41.6)	39.2 (31.8-46.6)	0.75	18.9 (17.2-20.6)	10.9 (9.4-12.5)	<0.001
Lifetime risk	409	179	72.3 (53.9-90.6)	53.1 (40.8-65.3)	0.09	21.1 (19.2-23.0)	11.6 (10.0-13.2)	<0.001

^*comparison women vs men

^†Cumulative incidence not corrected for competing causes of death

^‡Cumulative incidence, corrected for competing causes of death