Skip to main content
. 2014 Jul 10;9(7):e101685. doi: 10.1371/journal.pone.0101685

Table 1. Association analysis of genetic variants in DNA repair genes with the risk of NHL.

Stage 1 Stage 2 Stage 1 & 2 [Aggregate]
(650 Cases/965 Controls) (647 Cases/981 Controls) (1,297 Cases/1,946 Controls)
Gene Chr. SNP Minor Allele Allele Freq. OR (95% CI) P OR (95% CI) P OR (95% CI) P
ATM 11 rs227060 T 0.37 1.27 (1.07–1.49) 0.0057 1.30 (1.10–1.54) 0.0020 1.27 (1.13–1.43) 6.77×10−5
ATM 11 rs611646 T 0.45 1.24 (1.04–1.49) 0.016 1.30 (1.10–1.54) 0.0020 1.26 (1.12–1.43) 1.52×10−4
GTF2H1 11 rs4150606 A 0.50 0.82 (0.69–0.97) 0.021 0.81 (0.68–0.95) 0.013 0.81 (0.72–0.92) 6.68×10−4
MSH2 2 rs4952887 T 0.07 0.66 (0.47–0.91) 0.012 0.76 (0.58–1.01) 0.055 0.71 (0.57–0.87) 0.00128
MRE11A 11 rs625245 C 0.32 0.78 (0.65–0.93) 0.0066 0.84 (0.69–1.01) 0.059 0.81 (0.71–0.93) 0.0018
ATM 11 rs419716 T 0.42 0.8 (0.67–0.96) 0.014 0.85 (0.71–1.01) 0.056 0.83 (0.73–0.94) 0.0025
POLQ 3 rs702019 G 0.23 0.77 (0.62–0.95) 0.013 0.90 (0.74–1.09) 0.271 0.84 (0.73–0.96) 0.013
TDP1 14 rs7149962 C 0.06 1.49 (1.07–2.08) 0.020 1.19 (0.85–1.65) 0.307 1.33 (1.05–1.68) 0.019
NBS1 8 rs1805812 C 0.06 0.87 (0.59–1.27) 0.466 0.65 (0.46–0.94) 0.021 0.75 (0.58–0.97) 0.028
CCNH 5 rs3093819 T 0.46 1.14 (0.96–1.34) 0.128 1.13 (0.96–1.34) 0.139 1.14 (1.01–1.28) 0.030
MRE11A 11 rs10831227 A 0.34 0.93 (0.79–1.1) 0.382 0.83 (0.70–0.99) 0.035 0.88 (0.78–0.99) 0.030
CHEK1 11 rs565416 A 0.32 0.79 (0.66–0.94) 0.0075 0.99 (0.84–1.17) 0.892 0.88 (0.78–0.99) 0.037
MSH6 2 rs7562048 G 0.44 0.79 (0.66–0.93) 0.0062 0.98 (0.82–1.16) 0.818 0.88 (0.78–0.99) 0.039
NBS1 8 rs14448 C 0.06 0.99 (0.70–1.40) 0.936 1.61 (1.16–2.23) 0.0043 1.28 (1.01–1.62) 0.041
ATR 3 rs10804682 A 0.20 1.24 (1.02–1.51) 0.031 1.09 (0.90–1.32) 0.375 1.15 (1.01–1.32) 0.042

OR = odds ratio; CI = confidence interval.