Table 1. Association analysis of genetic variants in DNA repair genes with the risk of NHL.
Stage 1 | Stage 2 | Stage 1 & 2 [Aggregate] | ||||||||
(650 Cases/965 Controls) | (647 Cases/981 Controls) | (1,297 Cases/1,946 Controls) | ||||||||
Gene | Chr. | SNP | Minor Allele | Allele Freq. | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P |
ATM | 11 | rs227060 | T | 0.37 | 1.27 (1.07–1.49) | 0.0057 | 1.30 (1.10–1.54) | 0.0020 | 1.27 (1.13–1.43) | 6.77×10−5 |
ATM | 11 | rs611646 | T | 0.45 | 1.24 (1.04–1.49) | 0.016 | 1.30 (1.10–1.54) | 0.0020 | 1.26 (1.12–1.43) | 1.52×10−4 |
GTF2H1 | 11 | rs4150606 | A | 0.50 | 0.82 (0.69–0.97) | 0.021 | 0.81 (0.68–0.95) | 0.013 | 0.81 (0.72–0.92) | 6.68×10−4 |
MSH2 | 2 | rs4952887 | T | 0.07 | 0.66 (0.47–0.91) | 0.012 | 0.76 (0.58–1.01) | 0.055 | 0.71 (0.57–0.87) | 0.00128 |
MRE11A | 11 | rs625245 | C | 0.32 | 0.78 (0.65–0.93) | 0.0066 | 0.84 (0.69–1.01) | 0.059 | 0.81 (0.71–0.93) | 0.0018 |
ATM | 11 | rs419716 | T | 0.42 | 0.8 (0.67–0.96) | 0.014 | 0.85 (0.71–1.01) | 0.056 | 0.83 (0.73–0.94) | 0.0025 |
POLQ | 3 | rs702019 | G | 0.23 | 0.77 (0.62–0.95) | 0.013 | 0.90 (0.74–1.09) | 0.271 | 0.84 (0.73–0.96) | 0.013 |
TDP1 | 14 | rs7149962 | C | 0.06 | 1.49 (1.07–2.08) | 0.020 | 1.19 (0.85–1.65) | 0.307 | 1.33 (1.05–1.68) | 0.019 |
NBS1 | 8 | rs1805812 | C | 0.06 | 0.87 (0.59–1.27) | 0.466 | 0.65 (0.46–0.94) | 0.021 | 0.75 (0.58–0.97) | 0.028 |
CCNH | 5 | rs3093819 | T | 0.46 | 1.14 (0.96–1.34) | 0.128 | 1.13 (0.96–1.34) | 0.139 | 1.14 (1.01–1.28) | 0.030 |
MRE11A | 11 | rs10831227 | A | 0.34 | 0.93 (0.79–1.1) | 0.382 | 0.83 (0.70–0.99) | 0.035 | 0.88 (0.78–0.99) | 0.030 |
CHEK1 | 11 | rs565416 | A | 0.32 | 0.79 (0.66–0.94) | 0.0075 | 0.99 (0.84–1.17) | 0.892 | 0.88 (0.78–0.99) | 0.037 |
MSH6 | 2 | rs7562048 | G | 0.44 | 0.79 (0.66–0.93) | 0.0062 | 0.98 (0.82–1.16) | 0.818 | 0.88 (0.78–0.99) | 0.039 |
NBS1 | 8 | rs14448 | C | 0.06 | 0.99 (0.70–1.40) | 0.936 | 1.61 (1.16–2.23) | 0.0043 | 1.28 (1.01–1.62) | 0.041 |
ATR | 3 | rs10804682 | A | 0.20 | 1.24 (1.02–1.51) | 0.031 | 1.09 (0.90–1.32) | 0.375 | 1.15 (1.01–1.32) | 0.042 |
OR = odds ratio; CI = confidence interval.