Table 3.
Impact of MTHFR C677T on serum lipid levels (mmol/L)
| Group | Genotype | n | TC | TG | HDL-C | LDL-C |
|---|---|---|---|---|---|---|
|
All |
|
|
|
|
|
|
| |
CC |
700 |
5.04 ± 0.97 |
0.94 (0.52) |
1.66 ± 0.39 |
2.86 ± 0.90 |
| |
CT |
266 |
5.15 ± 1.01 |
0.98 (0.53) |
1.63 ± 0.39 |
3.01 ± 0.84 |
| |
TT |
43 |
4.86 ± 1.31 |
0.88 (0.41) |
1.61 ± 0.46 |
2.70 ± 0.98 |
| |
F |
— |
1.099 |
0.617 |
0.190 |
1.537 |
| |
p |
— |
0.334 |
0.540 |
0.827 |
0.215 |
| |
CC |
700 |
5.04 ± 0.97 |
0.94 (0.52) |
1.66 ± 0.39 |
2.86 ± 0.90 |
| |
CT/TT |
309 |
5.11 ± 1.06 |
0.96 (0.50) |
1.64 ± 0.41 |
2.97 ± 0.87 |
| |
F |
— |
0.163 |
1.335 |
0.022 |
0.001 |
| |
p |
— |
0.686 |
0.248 |
0.883 |
0.974 |
|
Male |
|
|
|
|
|
|
| |
CC |
178 |
5.00 ± 1.04 |
0.95 (0.70) |
1.61 ± 0.41 |
2.84 ± 0.96 |
| |
CT |
73 |
4.78 ± 0.97 |
0.87 (0.48) |
1.59 ± 0.42 |
2.72 ± 0.83 |
| |
TT |
18 |
4.70 ± 0.98 |
0.83 (0.45) |
1.68 ± 0.57 |
2.58 ± 0.73 |
| |
F |
— |
1.560 |
2.001 |
0.477 |
1.106 |
| |
p |
— |
0.212 |
0.137 |
0.621 |
0.332 |
| |
CC |
178 |
5.00 ± 1.04 |
0.95 (0.70) |
1.61 ± 0.41 |
2.84 ± 0.96 |
| |
CT/TT |
91 |
4.77 ± 0.97 |
0.86 (0.46) |
1.61 ± 0.45 |
2.69 ± 0.81 |
| |
F |
— |
3.042 |
3.837 |
0.025 |
1.830 |
| |
p |
— |
0.082 |
0.051 |
0.876 |
0.177 |
|
Female |
|
|
|
|
|
|
| |
CC |
522 |
5.05 ± 0.95 |
0.93 (0.49) |
1.68 ± 0.38 |
2.87 ± 0.88 |
| |
CT |
193 |
5.29 ± 0.99 |
1.02 (0.62) |
1.65 ± 0.38 |
3.12 ± 0.82 |
| |
TT |
25 |
4.97 ± 1.52 |
1.01 (0.43) |
1.61 ± 0.46 |
2.79 ± 1.13 |
| |
F |
— |
3.762 |
0.452 |
0.181 |
4.227 |
| |
p |
— |
0.024 |
0.637 |
0.835 |
0.015 |
| |
CC |
522 |
5.05 ± 0.95 |
0.93 (0.49) |
1.68 ± 0.38 |
2.87 ± 0.88 |
| |
CT/TT |
218 |
5.26 ± 1.06 |
1.02 (0.53) |
1.65 ± 0.39 |
3.08 ± 0.86 |
| |
F |
— |
4.183 |
0.766 |
0.232 |
4.504 |
| |
p |
— |
0.041 |
0.382 |
0.630 |
0.034 |
|
LG |
|
|
|
|
|
|
| |
CC |
332 |
5.12 ± 1.00 |
0.97 (0.49) |
1.59 ± 0.37 |
3.04 ± 0.87 |
| |
CT |
159 |
5.22 ± 1.06 |
0.99 (0.50) |
1.61 ± 0.38 |
3.09 ± 0.86 |
| |
TT |
25 |
5.13 ± 1.31 |
1.07 (0.44) |
1.56 ± 0.51 |
3.01 ± 0.96 |
| |
F |
— |
0.148 |
0.017 |
0.073 |
0.305 |
| |
p |
— |
0.863 |
0.983 |
0.930 |
0.737 |
| |
CC |
332 |
5.12 ± 1.00 |
0.97 (0.49) |
1.59 ± 0.37 |
3.04 ± 0.87 |
| |
CT/TT |
184 |
5.20 ± 1.09 |
1.00 (0.48) |
1.61 ± 0.40 |
3.08 ± 0.88 |
| |
F |
— |
0.276 |
0.003 |
0.000 |
0.558 |
| |
p |
— |
0.600 |
0.959 |
0.993 |
0.456 |
|
Male |
|
|
|
|
|
|
| |
CC |
83 |
5.00 ± 1.11 |
0.94 (0.39) |
1.57 ± 0.41 |
2.96 ± 0.95 |
| |
CT |
35 |
4.67 ± 1.11 |
0.87 (0.29) |
1.54 ± 0.39 |
2.67 ± 0.97 |
| |
TT |
9 |
4.71 ± 1.09 |
0.84 (0.53) |
1.55 ± 0.64 |
2.76 ± 0.77 |
| |
F |
— |
1.377 |
0.983 |
0.081 |
1.255 |
| |
p |
— |
0.256 |
0.377 |
0.922 |
0.289 |
| |
CC |
83 |
5.00 ± 1.11 |
0.94 (0.39) |
1.57 ± 0.41 |
2.96 ± 0.95 |
| |
CT/TT |
44 |
4.67 ± 1.09 |
0.87(0.34) |
1.54 ± 0.44 |
2.69 ± 0.92 |
| |
F |
— |
2.749 |
1.398 |
0.158 |
2.450 |
| |
p |
— |
0.100 |
0.239 |
0.691 |
0.120 |
|
Female |
|
|
|
|
|
|
| |
CC |
249 |
5.15 ± 0.96 |
0.98 (0.52) |
1.60 ± 0.35 |
3.06 ± 0.84 |
| |
CT |
124 |
5.37 ± 1.00 |
1.04 (0.62) |
1.63 ± 0.38 |
3.21 ± 0.80 |
| |
TT |
16 |
5.37 ± 1.40 |
1.09 (0.47) |
1.56 ± 0.44 |
3.15 ± 1.05 |
| |
F |
— |
2.179 |
2.148 |
0.605 |
1.188 |
| |
p |
— |
0.115 |
0.113 |
0.546 |
0.306 |
| |
CC |
249 |
5.15 ± 0.96 |
0.98 (0.52) |
1.60 ± 0.35 |
3.06 ± 0.84 |
| |
CT/TT |
140 |
5.37 ± 1.04 |
1.07 (0.61) |
1.63 ± 0.38 |
3.20 ± 0.83 |
| |
F |
— |
4.366 |
3.091 |
0.580 |
2.307 |
| |
p |
— |
0.037 |
0.080 |
0.447 |
0.130 |
|
Non-LG |
|
|
|
|
|
|
| |
CC |
368 |
4.97 ± 0.95 |
0.91 (0.60) |
1.73 ± 0.40 |
2.70 ± 0.90 |
| |
CT |
107 |
5.06 ± 0.92 |
0.95 (0.59) |
1.66 ± 0.41 |
2.90 ± 0.79 |
| |
TT |
18 |
4.47 ± 1.25 |
0.85 (0.24) |
1.75 ± 0.49 |
2.28 ± 0.86 |
| |
F |
— |
4.138 |
2.135 |
0.728 |
4.601 |
| |
p |
— |
0.017 |
0.119 |
0.483 |
0.010 |
| |
CC |
368 |
4.97 ± 0.95 |
0.91 (0.60) |
1.73 ± 0.40 |
2.70 ± 0.90 |
| |
CT/TT |
125 |
4.98 ± 1.00 |
0.89 (0.47) |
1.68 ± 0.42 |
2.81 ± 0.83 |
| |
F |
— |
0.137 |
1.833 |
0.032 |
0.128 |
| |
p |
— |
0.712 |
0.176 |
0.858 |
0.721 |
|
Male |
|
|
|
|
|
|
| |
CC |
95 |
4.99 ± 0.99 |
0.97 (0.91) |
1.63 ± 0.41 |
2.75 ± 0.96 |
| |
CT |
38 |
4.89 ± 0.83 |
0.89 (0.70) |
1.64 ± 0.45 |
2.76 ± 0.68 |
| |
TT |
9 |
4.69 ± 0.92 |
0.81 (0.49) |
1.81 ± 0.49 |
2.40 ± 0.68 |
| |
F |
— |
0.677 |
1.372 |
1.096 |
0.963 |
| |
p |
— |
0.510 |
0.257 |
0.337 |
0.384 |
| |
CC |
95 |
4.99 ± 0.99 |
0.97 (0.91) |
1.63 ± 0.41 |
2.75 ± 0.96 |
| |
CT/TT |
47 |
4.86 ± 0.84 |
0.85 (0.67) |
1.67 ± 0.46 |
2.69 ± 0.69 |
| |
F |
— |
0.670 |
2.637 |
0.537 |
0.212 |
| |
p |
— |
0.415 |
0.107 |
0.465 |
0.646 |
|
Female |
|
|
|
|
|
|
| |
CC |
273 |
4.96 ± 0.94 |
0.90 (0.52) |
1.76 ± 0.40 |
2.69 ± 0.88 |
| |
CT |
69 |
5.15 ± 0.96 |
1.00 (0.49) |
1.68 ± 0.38 |
2.97 ± 0.84 |
| |
TT |
9 |
4.26 ± 1.54 |
0.85 (0.24) |
1.70 ± 0.52 |
2.16 ± 1.05 |
| |
F |
— |
5.413 |
1.114 |
0.820 |
5.323 |
| |
p |
— |
0.005 |
0.330 |
0.441 |
0.005 |
| |
CC |
273 |
4.96 ± 0.94 |
0.90 (0.52) |
1.76 ± 0.40 |
2.69 ± 0.88 |
| |
CT/TT |
78 |
5.05 ± 1.07 |
0.95 (0.40) |
1.68 ± 0.40 |
2.88 ± 0.90 |
| |
F |
— |
0.287 |
0.063 |
1.727 |
1.594 |
| p | — | 0.592 | 0.803 | 0.190 | 0.208 |