Table 4.

Impact of MTHFR C677T on serum lipid levels according to lipid status (mmol/L)

Group	Genotype	n	TC	TG	HDL-C	LDL-C
LG
Dyslipidemia
	CC	167	5.84 ± 0.76	1.14 (0.69)	1.68 ± 0.39	3.57 ± 0.74
	CT	84	5.96 ± 0.75	1.16 (0.71)	1.70 ± 0.41	3.66 ± 0.70
	TT	10	6.30 ± 1.14	1.13 (1.10)	1.72 ± 0.66	3.80 ± 0.89
	F	—	1.265	0.120	0.501	0.431
	p	—	0.284	0.887	0.607	0.605
	CC	167	5.84 ± 0.76	1.14 (0.69)	1.68 ± 0.39	3.57 ± 0.74
	CT/TT	89	5.99 ± 0.81	1.16 (0.72)	1.71 ± 0.44	3.67 ± 0.72
	F	—	1.001	0.041	0.232	0.625
	p	—	0.318	0.839	0.631	0.430
Normolipidemia
	CC	165	4.38 ± 0.58	0.85 (0.33)	1.51 ± 0.32	2.49 ± 0.62
	CT	75	4.38 ± 0.65	0.85 (0.28)	1.51 ± 0.32	2.45 ± 0.52
	TT	15	4.35 ± 0.69	0.94 (0.47)	1.45 ± 0.36	2.48 ± 0.57
	F	—	0.021	0.228	0.240	0.222
	p	—	0.979	0.796	0.786	0.801
	CC	165	4.38 ± 0.58	0.85 (0.33)	1.51 ± 0.32	2.49 ± 0.62
	CT/TT	90	4.38 ± 0.65	0.85 (0.34)	1.50 ± 0.33	2.46 ± 0.53
	F	—	0.029	0.350	0.109	0.149
	p	—	0.865	0.555	0.742	0.700
Non-LG
Dyslipidemia
	CC	168	5.65 ± 0.92	1.16 (0.98)	1.71 ± 0.45	3.19 ± 1.00
	CT	53	5.77 ± 0.59	1.11 (1.06)	1.68 ± 0.43	3.43 ± 0.61
	TT	6	5.85 ± 0.39	0.85 (0.55)	2.19 ± 0.49	3.12 ± 0.46
	F	—	0.307	1.270	1.880	0.501
	p	—	0.736	0.283	0.155	0.606
	CC	146	5.71 ± 0.66	1.16 (0.98)	1.71 ± 0.41	3.43 ± 0.64
	CT/TT	58	5.76 ± 0.58	1.08 (1.13)	1.70 ± 0.42	3.45 ± 0.58
	F	—	−0.530	−0.443	0.121	−0.148
	p	—	0.597	0.658	0.903	0.883
Normolipidemia
	CC	200	4.40 ± 0.50	0.80 (0.34)	1.74 ± 0.36	2.29 ± 0.52
	CT	54	4.36 ± 0.58	0.69 (0.32)	1.65 ± 0.39	2.37 ± 0.56
	TT	12	3.79 ± 0.90	0.79 (0.24)	1.53 ± 0.33	1.86 ± 0.70
	F	—	7.662	0.987	1.272	5.337
	p	—	0.001	0.374	0.282	0.005
	CC	200	4.40 ± 0.50	0.80 (0.34)	1.74 ± 0.36	2.29 ± 0.52
	CT/TT	66	4.26 ± 0.68	0.75 (0.33)	1.63 ± 0.38	2.27 ± 0.61
	F	—	1.478	1.202	1.339	0.156
	p	—	0.225	0.274	0.248	0.694