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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: Inhal Toxicol. 2012 Dec;24(14):995–1008. doi: 10.3109/08958378.2012.745633

Figure 9.

Figure 9

Cathepsin B inhibitor blocks multi-walled carbon nanotubes (MWCNT)-induced NLRP3 inflammasome cytokines production. Freshly isolated alveolar macrophages (AM) from C57BL/6 mice were incubated in 100 μl at 106 cells/ml with 100 μg/ml high nickel (FA21) or low nickel (FA04) MWCNT for 24 h with or without 10 μM cathepsin B inhibitor CA-074-Me or 20 μM caspase 1 inhibitor Ac-Tyr-Val-Ala-Asp-CMK. (A) Bar graph showing the mean ± SEM IL-1β production and (B) bar graph showing the mean ± SEM IL-18 production. ***p < 0.001 compared to corresponding baseline condition by Bonferroni's test.