Table 2.
The list of the differentially regulated heart-failure-specific genes in dogs with ISACHC heart failure
| GeneSymbol | Adjusted p-values | Regulation | Description |
|---|---|---|---|
| ACTA1 | 0.014573121 | Up | Actin, alpha 1, skeletal muscle |
| ACTA2 | 0.039442863 | Up | Actin, alpha 2, smooth muscle, aorta |
| ACTC1 | 0.024042822 | Up | Actin, alpha, cardiac muscle 1 |
| ACTL7A | 0.024659734 | Up | Actin-like 7A |
| ADA | 0.01982955 | Up | Adenosine deaminase F |
| ATF4 | 0.044055864 | Up | Activating transcription factor 4 |
| CAMP | 0.018274972 | Up | Cathelicidin antimicrobial peptide |
| CAPG | 0.046687745 | Up | Capping protein (actin filament), gelsolin-like |
| CCL14 | 0.024452273 | Up | Chemokine (C-C motif) ligand 14 |
| CD151 | 0.012394691 | Up | CD151 molecule (Raph blood group) |
| CD177 | 0.010730711 | Up | CD177 molecule |
| CD300E | 0.0064891023 | Up | CD300e molecule |
| CORO1B | 0.03894925 | Up | Coronin, actin binding protein, 1B |
| CRYL1 | 0.0078813145 | Up | Crystallin, lambda 1 |
| CYBA | 0.031601883 | Up | Cytochrome b-245, alpha polypeptide |
| CYP27A1 | 0.034636706 | Up | Cytochrome P450, family 27, subfamily A, polypeptide 1 |
| DPEP2 | 0.008431375 | Up | Dipeptidase 2 |
| DSTN | 0.008163466 | Up | Destrin (actin depolymerizing factor) |
| EAF1 | 0.03957692 | Up | ELL associated factor 1 |
| EPHX2 | 0.018156866 | Up | Epoxide hydrolase 2, cytoplasmic |
| FAM107A | 0.020942843 | Up | Family with sequence similarity 107, member A |
| FANCG | 0.0043643974 | Down | Fanconi anemia, complementation group G |
| FLOT2 | 0.017366651 | Up | Flotillin 2 |
| GP9 | 0.0075741783 | Up | Glycoprotein IX (platelet) |
| GSN | 0.006870092 | Up | Gelsolin |
| HK3 | 0.0073725334 | Up | Hexokinase 3 (white cell) |
| HP | 0.016630936 | Up | Haptoglobin |
| HPCAL1 | 0.030948874 | Up | Hippocalcin-like 1 |
| IL10RA | 0.046400532 | Up | Interleukin 10 receptor, alpha |
| KDELR1 | 0.0037026592 | Up | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 |
| KLHDC8B | 0.015807072 | Up | Kelch domain containing 8B |
| LOC475113 | 0.008475645 | Up | Lymphocyte antigen 6B-like |
| LOC491090 | 0.027546933 | Up | Similar to tubulin, alpha 1 |
| LSM10 | 0.0052581653 | Up | LSM10, U7 small nuclear RNA associated |
| MAPK1 | 0.03080859 | Up | Mitogen-activated protein kinase 1 |
| ME1 | 0.016186723 | Up | Malic enzyme 1, NADP(+)-dependent, cytosolic |
| MMP8 | 0.008103578 | Up | Matrix metallopeptidase 8 (neutrophil collagenase) |
| MMRN1 | 0.005678207 | Up | Multimerin 1 |
| MOV10L1 | 0.012869541 | Up | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) |
| MRPL37 | 0.026399544 | Up | Mitochondrial ribosomal protein L37 |
| MVP | 0.008610116 | Up | Major vault protein |
| MYL6 | 0.032878894 | Up | Myosin, light chain 6, alkali, smooth muscle and non-muscle |
| MYL6B | 0.008475645 | Up | Myosin, light chain 6B, alkali, smooth muscle and non-muscle |
| N4BP2 | 0.01824313 | Down | NEDD4 binding protein 2 |
| NAGPA | 0.038744777 | Up | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase |
| NEIL1 | 0.030278882 | Down | Nei endonuclease VIII-like 1 (E. coli) |
| NQO2 | 0.037860617 | Up | NAD(P)H dehydrogenase, quinone 2 |
| NRGN | 0.014320144 | Up | Neurogranin (protein kinase C substrate, RC3) |
| NSG1 | 0.009202879 | Up | Neuron specific gene family member 1 |
| PARVB | 0.025306692 | Up | Parvin, beta |
| PCGF2 | 0.015807072 | Up | Polycomb group ring finger 2 |
| PGLYRP1 | 0.0151561815 | Up | Peptidoglycan recognition protein 1 |
| PPP1R3D | 0.0077612605 | Up | Protein phosphatase 1, regulatory (inhibitor) subunit 3D |
| PTGER3 | 0.0045230556 | Up | Prostaglandin E receptor 3 (subtype EP3) |
| PTPN9 | 0.008163466 | Up | Protein tyrosine phosphatase, non-receptor type 9 |
| RSU1 | 0.046061113 | Up | Ras suppressor protein 1 |
| SEPT5 | 0.0062189046 | Up | Septin 5 |
| SHC2 | 0.02669537 | Up | SHC (Src homology 2 domain containing) transforming protein 2 |
| SLC11A1 | 0.0045230556 | Up | Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 |
| SLC27A2 | 0.006745509 | Up | Solute carrier family 27 (fatty acid transporter), member 2 |
| SLC2A6 | 0.0045230556 | Up | Solute carrier family 2 (facilitated glucose transporter), member 6 |
| TBC1D30 | 0.030404283 | Up | TBC1 domain family, member 30 |
| TBXAS1 | 0.0049617672 | Up | Thromboxane A synthase 1 (platelet) |
| TCIRG1 | 0.023556981 | Up | T-cell, immune regulator 1, ATPase, H + transporting, lysosomal V0 subunit A3 |
| TIMP1 | 0.0043643974 | Up | TIMP metallopeptidase inhibitor 1 |
| TOP3B | 0.02519754 | Up | Topoisomerase (DNA) III beta |
| TRPV2 | 0.0049617672 | Up | Transient receptor potential cation channel, subfamily V, member 2 |
| TSPO | 0.004600876 | Up | Translocator protein (18 kDa) |
| TTC19 | 0.0075741783 | Down | Tetratricopeptide repeat domain 19 |
| VNN1 | 0.031601883 | Down | Vanin 1 |
| ZNF248 | 0.004831977 | Down | Zinc finger protein 248 |