Table 6.
Ariadne pathways based on ISACHC3-specific genes differentially regulated in dogs with ISACHC3 heart failure
| Ariadne receptor signaling pathways | The number of genes | p-value |
|---|---|---|
| HGFR - > FOXO3A signaling | 3 | 0.00563574 |
| ERBB2/3 - > EP300/ETS/ETV/SP1 signaling | 5 | 0.01015 |
| EGFR/ERBB2 - > HIF1A signaling | 5 | 0.0128385 |
| TNFRSF5/13B - > NFATC1 signaling | 3 | 0.0152928 |
| HGFR - > AP-1/CREB/MYC signaling | 5 | 0.0216208 |
| AdenosineR - > NF-kB signaling | 4 | 0.0217062 |
| ICAM2 - > CTNNB/FOXO/STAT3 signaling | 3 | 0.0242659 |
| NeurotensinR - > ELK-SRF/AP-1/EGR signaling | 5 | 0.0248821 |
| IL2R - > ELK-SRF/MYC signaling | 4 | 0.0259176 |
| InsulinR - > ELK-SRF/SREBF signaling | 4 | 0.0274252 |
| GHR - > ELK-SRF/MYC signaling | 4 | 0.0274252 |
| KIT - > MITF signaling | 4 | 0.032265 |
| IGF1R - > MEF/MYOD/MYOG signaling | 4 | 0.033985 |
| UrokinaseR - > ELK-SRF signaling | 4 | 0.0357589 |
| IL4R - > ELK-SRF/HMGY signaling | 4 | 0.0375869 |
| FibronectinR - > CTNNB signaling | 3 | 0.0381165 |
| EDG2 - > ELK-SRF signaling | 4 | 0.0394692 |
| EGFR/ERBB3 - > MEF/MYOD/NFATC/MYOG signaling | 6 | 0.0414187 |
| FcIgER - > ELK-SRF signaling | 4 | 0.0433973 |
| EGFR - > NCOR2 signaling | 4 | 0.0454432 |
| GDNF - > HSF1 signaling | 4 | 0.047544 |
| ErythropoietinR - > ELK-SRF/FOS signaling | 5 | 0.0477064 |