Table 3.
Correlations Between Fold-Increase of Hemagglutinin Inhibition and Virus Neutralization Titers and Interferon (IFN)–Related Modules and Genes, by Vaccine and Time After Vaccine Receipt
| Variable | Median Expression, Fold-Increase |
|||||
|---|---|---|---|---|---|---|
| H1N1 |
H3N2 |
B |
||||
| r | P | r | P | r | P | |
| HI titer 1 d after TIV receipt | ||||||
| IFN (161 genes) | −0.22 | .444 | 0.531 | .049 | −0.112 | .742 |
| M1.2 | −0.134 | .637 | 0.633 | .013 | −0.0745 | .844 |
| M3.4 | −0.244 | .39 | 0.531 | .049 | −0.0373 | .913 |
| M5.12 | −0.179 | .532 | 0.592 | .024 | 0.0745 | .844 |
| OASL | −0.141 | .615 | 0.695 | <.01 | −0.186 | .612 |
| OAS3 | −0.271 | .34 | 0.493 | .069 | −0.0373 | .913 |
| IFIT1 | −0.0941 | .738 | 0.571 | .032 | −0.112 | .742 |
| IFIT3 | −0.114 | .693 | 0.585 | .026 | 0 | .983 |
| IFI44L | −0.184 | .521 | 0.578 | .029 | −0.0373 | .913 |
| RSAD2 | −0.224 | .435 | 0.507 | .061 | −0.0373 | .913 |
| ISG15 | 0.0291 | .916 | 0.659 | .010 | −0.149 | .676 |
| GBP1 | 0.125 | .659 | 0.566 | .033 | 0.224 | .55 |
| GBP4 | −0.152 | .594 | 0.469 | .087 | 0.0373 | .913 |
| LOC400759 | −0.213 | .453 | 0.393 | .157 | 0.0373 | .913 |
| VN titer 1 d after TIV receipt | ||||||
| IFN (161 genes) | 0.075 | .792 | 0.372 | .199 | 0.346 | .219 |
| M1.2 | 0.0417 | .878 | 0.468 | .102 | 0.487 | .074 |
| M3.4 | 0.0861 | .764 | 0.372 | .199 | 0.373 | .184 |
| M5.12 | 0.136 | .643 | 0.476 | .093 | 0.459 | .094 |
| OASL | 0.158 | .591 | 0.378 | .192 | 0.466 | .087 |
| OAS3 | 0.114 | .696 | 0.358 | .221 | 0.403 | .148 |
| IFIT1 | 0.161 | .591 | 0.4 | .166 | 0.444 | .109 |
| IFIT3 | 0.0611 | .835 | 0.471 | .097 | 0.351 | .212 |
| IFI44L | 0.103 | .723 | 0.42 | .148 | 0.496 | .069 |
| RSAD2 | 0.0667 | .821 | 0.4 | .166 | 0.493 | .069 |
| ISG15 | 0.211 | .481 | 0.48 | .093 | 0.505 | .0636 |
| GBP1 | 0.0139 | .949 | 0.664 | .012 | 0.568 | .032 |
| GBP4 | −0.0889 | .764 | 0.414 | .154 | 0.38 | .173 |
| LOC400759 | −0.383 | .186 | 0.324 | .269 | 0.199 | .482 |
| VN titer 7 d after LAIV receipt | ||||||
| IFN (161 genes) | −0.616 | .233 | 0.934 | <.001 | 0.581 | .087 |
| M1.2 | −0.41 | .45 | 0.889 | <.001 | 0.641 | .058 |
| M3.4 | −0.462 | .45 | 0.921 | <.001 | 0.359 | .308 |
| M5.12 | −0.616 | .233 | 0.83 | <.001 | 0.419 | .243 |
| OASL | −0.462 | .45 | 0.937 | <.001 | 0.641 | .058 |
| OAS1 | −0.359 | .517 | 0.74 | <.01 | 0.197 | .58 |
| OAS2 | 0.205 | .683 | 0.762 | <.01 | 0.65 | .050 |
| IFIT1 | −0.103 | .783 | 0.762 | <.01 | 0.522 | .138 |
| IFIT3 | −0.41 | .45 | 0.921 | <.001 | 0.41 | .243 |
| IFITM3 | −0.616 | .233 | 0.791 | <.01 | 0.624 | .067 |
| RSAD2 | −0.41 | .45 | 0.889 | <.001 | 0.641 | .058 |
| RTP4 | −0.718 | .133 | 0.525 | .107 | 0.539 | .124 |
| GBP1 | −0.872 | .083 | 0.869 | <.001 | 0.641 | .058 |
| GBP5 | −0.205 | .683 | 0.701 | .021 | −0.00855 | .948 |
IFN, 161 genes (M1.2 + M3.4 + M5.12). M1.2: IFN module. M3.4: IFN module. M5.12: IFN module.
Abbreviations: LAIV, live attenuated influenza vaccine; TIV, trivalent inactivated influenza vaccine.