Table 3.

Multivariable Cox proportional hazards regression analysis

	Hazard ratio (95% CI)	P
ECOG PS ≥2	1.51 (1.03–2.21)	0.036
≥2 visceral or bone metastases	1.73 (1.14–2.64)	0.011
Corrected serum calcium >10 mmol/l	2.07 (1.31–3.27)	0.002
Serum LDH > ULN	1.55 (1.06–2.27)	0.023
Platelet count > ULN	1.65 (1.03–2.66)	0.039
Absolute lymphocyte count < LLN	1.84 (1.18–2.88)	0.009
Retroperitoneal lymph node metastasis (N2)	2.15 (1.43–3.23)	<0.001
Current smoker	1.71 (1.06–2.78)	0.030

ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase; LLN, lower limit of normal; PS, performance status; ULN, upper limit of normal.