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Domain organization of RTKs. The following abbreviations are used: L, leucine-rich; CR, cysteine-rich; Ig, immunoglobulin-like; FnIII, fibronectin type III; ID, insert domain. The L1, CR1, L2 and CR2 domains of the ErbB family are alternatively termed Domains I–IV. The ErbB and Trk families are drawn as a monomer, but might be present as non-covalently formed dimers at the cell surface prior to ligand binding (see the main text). Not drawn to scale.
