Table 1.

Expression of the TRPC channel and its properties in neuronal cells.

Subfamily	Cellular expression in Neurons	Ion channel properties	References
TRPC1	Brain, retina, peripheral axons and the mechanosensory terminals	Non selective, 16 pS current conductance, non-rectifying or mildly inward rectifying with a reverse potential of about +10 mV	[27,28,29,30]
TRPC2	Dendritic tips of the vomeronasal sensory neurons and spermatozoa (mouse)	Partially selective with a Pca/PNa ratio of 2.7, 42 pS current conductance, non-rectifying	[31,32]
TRPC3	Central nervous system (CNS)	Non selective, 60–66 pS current conductance, slightly dual (inward and outward) rectifying with a reverse potential of +5 mV	[33,34,35,36]
TRPC4	CNS, retina	Non selective, 30–42 pS current conductance, dual (inward and outward) rectifying with a reverse potential of about +10 mV	[37,38,39,40]
TRPC5	Brain, especially in fetal brain	Partially selective with a Pca/PNa ratio of 9, 47–66 pS current conductance, dual (inward and outward) rectifying as a homomer, outwardly rectifying when expressed with TRPC1 or TRPC4	[30,38,40,41,42,43]
TRPC6	Brain, retina	Partially selective with a Pca/PNa ratio of 5, 28–37 pS current conductance, dual (inward and outward) rectifying or inward rectifying	[33,35,44,45,46]
TRPC7	CNS (human); weak in CNS (mouse)	Partially selective with a Pca/PNa ratio of 5.9, 25–50 pS current conductance, slightly outward rectifying	[35,44,47,48]