Table 4.
Classification performance measurements from three tools (%).
| Classification | Sensitivity | Specificity | Accuracy | Precision | F-Measure | AUC |
|---|---|---|---|---|---|---|
| SIFT | ||||||
| Disease/neutral | 71.1 | 71.1 | 71.1 | 75.1 | 73.1 | 77.3 |
| PGx/disease | 71.1 | 60.6 | 65.8 | 90.3 | 79.6 | 70.5 |
| PGx/neutral | 54.8 | |||||
| PolyPhen2 | ||||||
| Disease/neutral | 85.3 | 57.1 | 71.2 | 72.7 | 78.5 | 76.9 |
| PGx/disease | 85.3 | 54.0 | 69.6 | 90.6 | 87.8 | 69.9 |
| PGx/neutral | 53.8 | |||||
| MutPred | ||||||
| Disease/neutral | 98.5 | 76.6 | 87.5 | 84.9 | 91.2 | 95.1 |
| PGx/disease | 98.5 | 61.1 | 79.8 | 92.9 | 95.6 | 85.9 |
| PGx/neutral | 59.1 |
Classification thresholds between PGx and neutral variants are unknown and thus only AUC was computed for each tool.