Table 8.
Functional annotation clusters of down-regulated genes in uterine endometrium on D15 of pregnancy compared with those on D15 of the estrous cycle
| Annotation clustera | Enrichment scoreb | Biological termsc |
|---|---|---|
| 1 | 1.68 | Adenyl ribonucleotide binding (15), purine ribonucleotide binding (17), purine nucleotide binding (17), ribonucleotide binding (17), nucleoside binding (15), adenyl nucleotide binding (15), purine nucleoside binding (15), ATP binding (14), nucleotide binding (18) |
| 2 | 1.50 | Cytoskeletal part (11), microtubule cytoskeleton (7), intracellular non-membrane- bounded organelle (18), non-membrane- bounded organelle (18), centrosome (4), cytoskeleton (13), microtubule organizing center (4) |
| 3 | 1.50 | Cytoskeletal part (11), dynein complex (3), microtubule associated complex (4), microtubule-based movement (4), microtubule cytoskeleton (7), motor activity (3), microtubule motor activity (3), microtubule (4), microtubule-based process (4) |
| 4 | 1.20 | Cytoskeletal part (11), regulation of actin filament length (3), regulation of cellular component size (5), regulation of actin cytoskeleton organization (3), regulation of actin filament-based process (3), regulation of organelle organization (4), actin cytoskeleton (4), cytoskeletal protein binding (6), regulation of cytoskeleton organization (3), actin binding (4) |
| 5 | 1.17 | Regulation of neuron differentiation (4), regulation of neurogenesis (4), regulation of nervous system development (4), regulation of cell development (4), neuron differentiation (4) |
| 6 | 0.92 | Protein amino acid dephosphorylation (4), dephosphorylation (4), phosphorus metabolic process (9), phosphoprotein phosphatase activity (4), phosphate metabolic process (9), protein tyrosine phosphatase activity (3), phosphatase activity (4), protein kinase activity (5), protein serine/threonine kinase activity (4), protein amino acid phosphorylation (5), phosphorylation (5) |
| 7 | 0.84 | Central nervous system neuron axonogenesis (3), central nervous system neuron development (3), central nervous system neuron differentiation (3), cell projection organization (5), cell motion (5), axonogenesis (3), cell morphogenesis involved in neuron differentiation (3), neuron projection morphogenesis (3), cell projection morphogenesis (3), cell morphogenesis involved in differentiation (3), cell part morphogenesis (3), neuron differentiation (4), neuron projection development (3), cell morphogenesis (3), cellular component morphogenesis (3), neuron development (3) |
| 8 | 0.82 | Regulation of synaptic transmission (3), regulation of transmission of nerve impulse (3), regulation of neurological system process (3), regulation of system process (4) |
| 9 | 0.75 | Cell projection organization (5), cytoskeletal protein binding (6), cytoskeleton organization (3) |
| 10 | 0.71 | Learning or memory (3), neurological system process (10), behavior (5), cognition (4) |
Top ten of annotation clusters identified by official gene symbols of up-regulated gene list on D15 of pregnancy compared with those on D15 of the estrous cycle.
Enrichment score represents significance of each cluster annotation and the relatedness of the terms and the genes associated with terms. Enrichment score is calculated by overall EASE scores (the modified Fisher extract p value) of each term member.
The gene ontology (GO) terms are group of terms having similar biological meaning with respect to biological process, cellular component, and molecular function. GO functional annotation term (FAT) was used for the analysis because GO term cannot universally define the specificity of a given term. The number in parenthesis indicate the number of differentially expressed genes contribute to the clustered term.