Table 3.
NLRP3 alleles and genotypes associated with digestive disorders in rabbit
| Models | Genotypes/allele | Cases (%) n = 162 | Controls (%) n = 102 | OR (95% CI) | p values |
|---|---|---|---|---|---|
| c.456C | 157 (48%) | 61 (30%) | 1.00 | <0.0001 | |
| c.456G | 167 (52%) | 143 (70%) | 0.4537(0.3132–0.6573) | ||
| Co-dominant | G/G | 27 (16.7%) | 51 (50%) | 1 | <0.0001 |
| G/C | 113 (69.8%) | 41 (40.2%) | 0.19 (0.11–0.35) | ||
| C/C | 22 (13.6%) | 10 (9.8%) | 0.24 (0.10–0.58) | ||
| Dominant | G/G | 27 (16.7%) | 51 (50%) | 1 | <0.0001 |
| G/C-C/C | 135 (83.3%) | 51 (50%) | 0.20 (0.11–0.35) | ||
| Recessive | G/G-G/C | 140 (86.4%) | 92 (90.2%) | 1 | 0.35 |
| C/C | 22 (13.6%) | 10 (9.8%) | 0.69 (0.31–1.53) | ||
| Over-dominant | G/G-C/C | 49 (30.2%) | 61 (59.8%) | 1 | <0.0001 |
| G/C | 113 (69.8%) | 41 (40.2%) | 0.29 (0.17–0.49) | ||
| Log-additive | - | - | - | 0.35 (0.23–0.55) | <0.0001 |
| c.594G | 200 (0.62) | 108 (0.53) | 1.00 | 0.0463 | |
| c.594T | 124 (0.38) | 96 (0.47) | 0.6975(0.4892–0.9944) | ||
| Co-dominant | G/G | 51 (31.5%) | 51 (31.5%) | 1 | 0.0008 |
| G/T | 98 (60.5%) | 98 (60.5%) | 0.77 (0.44–1.36) | ||
| T/T | 13 (8%) | 13 (8%) | 3.16 (1.41–7.08) | ||
| Dominant | G/G | 51 (31.5%) | 51 (31.5%) | 1 | 0.85 |
| G/T-T/T | 111 (68.5%) | 111 (68.5%) | 1.05 (0.62–1.80) | ||
| Recessive | G/G-G/T | 149 (92%) | 149 (92%) | 1 | 0.0002 |
| T/T | 13 (8%) | 13 (8%) | 3.72 (1.80–7.68) | ||
| Over-dominant | G/G-T/T | 64 (39.5%) | 64 (39.5%) | 1 | 0.014 |
| G/T | 98 (60.5%) | 98 (60.5%) | 0.54 (0.32–0.89) | ||
| Log-additive | - | - | - | 1.51 (1.03–2.23) | 0.033 |
OR = Odds ratio, CI = Confidence interval.