Table 8.
Endoscopic ultrasound-guided plexus neurolysis/celiac plexus block n (%)
| Ref. | Design | Indications | Techniques | Technical success | Clinical success (pain relief) | Complications |
| Wiersema et al[167] | RS | PC (n = 25) | CPN | 100% | 79%-88% | 4 transient diarrhea |
| Metastases (n = 5) | ||||||
| Gress et al[163] | RCT | CP (n = 10) | EUS-guided | 100% | 50% | None |
| CP (n = 8) | CT-guided | 25% | ||||
| Gunaratnam et al[168] | PS | PC (n = 58) | CPN | 100% | 78% | 5 transient abdominal pain |
| Gress et al[169] | PS | CP (n = 90) | CPB | 100% | 55% | 3 diarrhea |
| Tran et al[170] | RS | PC (n = 10) | CPN | 100% | 70% | NR |
| Ramirez-Luna et al[171] | RS | PC (n = 11) | CPN | 100% | 72.20% | None |
| Levy et al[172] | RS | PC (n = 18) | CGN (n = 17) | NR | 16/17 (94) | 12 hypotension |
| CGB (n = 1) | 0/1 (0) | 6 diarrhea | ||||
| CP (n = 18) | CGN (n = 5) | NR | 4/5 (80) | |||
| CGB (n = 13) | 5/13 (38) | |||||
| O'Toole et al[173] | RS | PC (n = 2) | CPB (n = 189) | NR | NR | 2 post-procedural pain |
| CP (n = 187) | 1 retroperitoneal abscess | |||||
| PC (n = 21) | CPN (n = 31) | NR | NR | 1 hypotension | ||
| CP (n = 10) | ||||||
| Santosh et al[164] | RCT | CP (n = 27) | EUS-CPB | 100% | 70% | 2 diarrhea |
| CP (n = 29) | Percutaneous-CPB | - | 30% | |||
| Leblanc et al[165] | RCT | CP (n = 23) | CPB (central) | 100% | 15/23 (65) | None |
| CP (n = 27) | CPB (bilateral) | 16/27 (59) | ||||
| Sahai et al[174] | RS | PC (n = 34)/CP (n = 37) | Central CPN | 100% | 45.90% | 1 adrenal artery bleeding |
| PC (n = 45)/CP (n = 44) | Bilateral CPN | 70.40% | ||||
| Sakamoto et al[175] | PS | PC (n = 67) | 34CPN | 100% | 72%-79% | None |
| 33 BPN | 96.90% | 19%-78% | ||||
| Wyse et al[158] | RCT | PC (n = 96) | 48 CPN | 100% | 60.70% | None |
| 48 control | - | - | ||||
| LeBlanc et al[160] | RCT | PC (n = 29) | CPB (central) | 100% | 20/29 (69) | None |
| PC (n = 21) | CPB (bilateral) | 17/21 (81) | ||||
| Téllez-Ávila et al[161] | RS | PC (n = 53) | Central (n = 21) | NR | 10/21 (48) | None |
| Bilateral (n = 32) | 18/32 (56) | |||||
| Iwata et al[176] | RS | PC (n = 47) | CPN | 100% | 68.10% | NR |
| Ascunce et al[177] | RS | PC (n = 64) | CPN | 100% | 50% | 1 hypotension |
| Stevens et al[166] | RCT | CP (n = 40) | Triamcinolone + bupivacaine (n = 21) | 100% | 68.4%-85.7% | 1 severe hypertension |
| Bupivacaine (n = 19) | 4 pain exacerbation | |||||
| 1 gastric hematoma | ||||||
| Wiechowska-Kozlowska et al[178] | RS | PC (n = 29) | CPN | 100% | 86% | 3 diarrhea |
| 1 hypotonia | ||||||
| 2 post-procedural pain | ||||||
| Wang et al[179] | PS | PC (n = 23) | Celiac ganglion irradiation | 100% | 82.60% | None |
| Leblanc et al[180] | PS | PC (n = 20) | 10 mL (n = 10) | 100% | 80% | 3 nausea and vomiting |
| 20 mL (n = 10) | 100% | 2 diarrhea | ||||
| 1 lightheadness | ||||||
| Seicean et al[181] | PS | PC (n = 32) | CPN | 100% | 75% | NR |
| Doi et al[162] | RCT | PC (n = 68) | CPN (n = 34) | 100% | 45.50% | 1 GI bleeding |
| CGN (n = 34) | 88.20% | 73.50% | 3 hypotension | |||
| 5 diarrhea | ||||||
| 17 pain exacerbation | ||||||
| Total | 23 studies | 1327 | - | 100% (88.2%-100%) | 71.9% (45.5%-90%) | - |
RCT: Randomized controlled trial; PS: Prospective study; RS: Retrospective study; PC: Pancreatic cancer; CP: Chronic pancreatitis; CPN: Celiac plexus neurolysis; CPB: Celiac plexus block; CT: Computed tomography; CGB: Celiac ganglia block; CGN: Celiac ganglia neurolysis; NR: Not reported.