Table 3.
Diagnostic value of clinical factors for clinically relevant postoperative pancreatic fistula
| Variable |
Univariate |
Multivariable |
||||
| Odds ratio | 95%CI | P value | Odds ratio | 95%CI | P value | |
| Age (≥ 65 yr) | 1.16 | 0.61-2.23 | 0.654 | |||
| Gender (male) | 1.29 | 0.66-2.53 | 0.459 | |||
| Diabetes mellitus | 1.39 | 0.67-2.92 | 0.378 | |||
| History of pancreatitis | 0.62 | 0.23-1.59 | 0.321 | |||
| Body mass index (≥ 22) | 1.48 | 0.79-2.82 | 0.226 | |||
| Operative procedure (DP) | 1.65 | 0.83-3.28 | 0.151 | |||
| Invasive carcinoma of the pancreas | 2.31 | 1.21-4.47 | 0.011 | 2.94 | 1.08-8.55 | 0.035 |
| Operative time (≥ 360 min) | 1.33 | 0.71-2.53 | 0.376 | |||
| Blood loss (≥ 600 mL) | 1.83 | 0.97-3.51 | 0.063 | 1.73 | 0.62-4.86 | 0.297 |
| Intraoperative transfusion | 1.45 | 0.48-4.59 | 0.511 | |||
| Pancreas texture (soft) | 1.46 | 0.69-3.10 | 0.322 | |||
| Main pancreatic duct (< 4 mm) | 1.36 | 0.70-2.65 | 0.366 | |||
| Persistence of high fever (≥ 38 °C, ≥ 3 d) | 1.10 | 0.57-2.14 | 0.781 | |||
| Persistence of SIRS (≥ 3 d) | 1.68 | 0.88-3.23 | 0.116 | |||
| Usage of catecholamines | 1.73 | 0.68-4.62 | 0.251 | |||
| Total lymphocyte count (< 600/mm3, POD 3) | 1.73 | 0.74-4.23 | 0.201 | |||
| Platelet count (< 164000/mm3, POD 3) | 2.28 | 1.20-4.39 | 0.012 | 1.28 | 0.44-3.64 | 0.646 |
| CRP (≥ 158 mg/L, POD 3) | 4.82 | 2.37-10.2 | < 0.001 | 2.39 | 0.73-8.03 | 0.150 |
| Neutrophil-to-lymphocyte ratio (≥ 9.6, POD 3) | 1.84 | 0.97-3.52 | 0.061 | 1.56 | 0.55-4.40 | 0.401 |
| CRP elevation (≥ 28.4 mg/L, POD 1 to 3) | 11.4 | 4.35-34.3 | < 0.001 | 4.82 | 1.25-20.2 | 0.022 |
| Drain amylase (≥ 1918 IU/mL, POD 3) | 3.00 | 1.57-5.86 | 0.001 | 1.50 | 0.55-4.08 | 0.423 |
| Drain fluid bacterial culture (positive, POD 3) | 1.62 | 0.68-3.87 | 0.278 | |||
Analyzed by binomial logistic analyses. DP: Distal pancreatectomy; SIRS: Systemic inflammatory response syndrome; CRP: C-reactive protein; POD: Postoperative day.