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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: Epilepsia. 2012 Jun;53(0 1):26–34. doi: 10.1111/j.1528-1167.2012.03472.x

Figure 1.

Figure 1

Quantitative gradients across the BBB and their predicted effect on neuronal excitability. The size of the molecules and ions depicted on the left side of the figure are roughly proportional to their trans-BBB concentrations. The brain concentration changes indicated by arrows is a semiquantitative means of showing what expected after BBB disruption. The predicted effect on neuronal excitability is also shown. BBB “openings” of different duration and extent and occurring in different regions of the brain may have distinctly different effects.