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. 2014 Apr 16;16(2):63–75. doi: 10.3727/105221614X13919976902219

Figure 2.

Figure 2

Effects of Med1 null on PPARα ligand induced responses in liver. Med1 liver null mice treated with Wy-14,643 (0.125% w/w) for 2 weeks (A, B, and C) and for 6 months (D, E, and F). Immunohistochemical localization of Med1 in Med1 liver conditional null mouse demonstrating absence of Med1 nuclear staining in hepatocytes except for positive staining for Med1 in few hepatocytes (A) and expanding colonies of escaped Cre deletion of large hepatocytes (D). These expanding colonies also reveal abundant cytoplasmic expression of L-PBE (F).