Table 1.

Nuclear Receptors in Liver Regeneration

Nuclear Receptor	Nuclear Receptor Responsive Element	Natural Ligands	Synthetic Ligands	Function: Lipogenesis Versus Fatty Acid Oxidation	Function: Liver Regeneration
PPARα	5′-AGGTCA(N)AGGTCA-3′	Free fatty acids Fatty acid derivatives	Fibrates Wy-14,643 Ciprofibrates	Increases fatty acid oxidation	Increases
PPARγ	5′-AGGTCA(N)AGGTCA-3′	Free fatty acids Fatty acid derivatives	Glitazones	Increases lipid storage/lipogenesis	Increases
LXRα,β	5′-(A/G)G(G/T)T(C/T)Annnn-(A/G)G(G/T)T(C/T)A-3′	Oxysterols	T0901317 GW3965	Increases lipogenesis	Decreases
FXR	5′-AGAGCA(N)AGGGGA-3′	Bile acids Oxysterols Polyunsaturated fatty acids	GW4064 6ECDCA MFA1 Obeticholic acid	Decreases lipogenesis	Increases
CAR	5′-(A/G)GTTCAnnnn-(A/G)GTTCA-3′	Xenobiotics Androstenol	Phenobarbital TCPOBOP Antimalarial drug artemisinin	Decreases lipogenesis/increases fatty acid oxidation	Increases
PXR	5′-(A/G)GTTCAnnnn-(A/G)GTTCA-3′	Bile acids Cholesterol derived 5-cholestane-3, 7, 12-triol	Drugs Xenobiotics	Decreases lipogenesis/fatty acid oxidation	Increases
TR	5′-(A/G)GGTCAnnnn-(A/G)GGTCA-3′	T3 and T4	CO23,GC-1 KB-141 KB2115 MB07811	Increases fatty acid oxidation	Increases