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. 2014 Jun;88(11):6368–6379. doi: 10.1128/JVI.00332-14

TABLE 1.

Serum neutralizing-antibody titers of immunized groups of mice

Vaccination typea Adjuvant Mean log serum neutralizing-antibody titer ± SEMb (statistical group[s])c
Preimmunization 14 days postimmunization 5 days postchallenge
Mock None <3.0 <3.0 <3.0
M-VLP None <3.0 <3.0 <3.0
M-VLP TMG <3.0 <3.0 ≤3.0
M-VLP αGC <3.0 <3.0 3.6 ± 0.6 (A)
F-VLP None <3.0 4.0 ± 0.2 (A) 4.3 ± 0.3 (A)
F-VLP TMG <3.0 6.1 ± 0.7 (B) 9.2 ± 0.7 (A, B, C)
F-VLP αGC <3.0 7.7 ± 0.7 (B, C) 7.4 ± 0.3 (C, D)
HMPV None <3.0 9.0 ± 0.1 (C) 8.8 ± 0.8 (B, D)
a

Mice were inoculated in the i.p. cavity with vaccine preparations on days 0 and 14, except that the HMPV group was infected i.n. on day 0.

b

Serum samples were collected preimmunization, 14 days after primary immunization before boost inoculation, and 5 days after HMPV i.n. infection. Titers of neutralizing antibody against HMPV were determined with an HMPV plaque reduction assay. The neutralizing-antibody titer was calculated as the antibody dilution at which the HMPV plaque number was reduced by 50%, based upon nonlinear regression analysis.

c

Mean antibody titers were compared by one-way ANOVA and assigned to statistically similar groups by using Tukey's multiple-comparison test. Values within a column that have a letter in common do not differ significantly (P > 0.05).