FIG 1.
The hepatic expression of miR-122 is associated with early virological response. The expression of miR-122 was assessed by RT-qPCR. The ΔCp (ΔCpt = 2ΔCpsample) of miR-122 was calculated and normalized to the ΔCp value of SNORD44 in each biopsy specimen. The histograms represent the mean log expression of miR-122/SNORD44 within the groups of patients, comprising those with sustained virological response (SVR), nonresponse or relapse (NR/RR), primary nonresponse (pNR), and complete early virological response (cEVR), normalized to the expression of miR-122 within the group of histologically normal liver biopsy specimens. (A) The hepatic expression of miR-122 was compared in patients with pNR and cEVR. (B) The hepatic expression of miR-122 was compared in patients with NR/RR and SVR. The nonparametric Wilcoxon Mann-Whitney test was used to compare miR-122 expression. The numbers in parentheses show the number of patients in each group.