FIG 2.
The IFNL3 CC genotype is associated with accumulation of hepatic miR-122. The expression of miR-122 was assessed by RT-qPCR. The ΔCp (ΔCpt = 2ΔCpsample) of miR-122 was calculated and normalized to the ΔCp value of SNORD44 in each biopsy specimen. (A to D) The histograms represent the mean log expression of miR-122/SNORD44 for all patients (A), patients who failed to respond to the treatment (NR/RR) (B), and SVR patients (C). The boxes and whiskers are as described in the legend to Fig. 1. We used the nonparametric Wilcoxon Mann-Whitney test to compare the expression of miR-122 in IFNL3 CC and CT/TT patients. (D) Reduction of hepatic expression of miR-122 in IFNL3 CT/TT patients who failed to respond to the treatment. The histograms represent the mean expression of miR-122/SNORD44 in IFNL3 CC and CT/TT patients with either SVR or NR/RR, normalized to the expression of miR-122 within the group of histologically normal liver biopsy specimens. The errors bars represent the standard deviations. The numbers in parentheses show the number of patients within each group.