TABLE 2.
Univariate analysis of relationship between log expression of hepatic miR-122 and binary clinicobiological variablesa
| Variable | No. of patients | Mean (SE) | P value | Mean difference (SE) |
|---|---|---|---|---|
| Age (yr) | ||||
| <45 | 48 | −0.01 (0.59) | ||
| ≥45 | 84 | −0.13 (0.62) | 0.28 | −0.12 (0.01) |
| Gender | ||||
| Female | 50 | −0.08 (072) | ||
| Male | 83 | −0.10 (0.54) | 0.90 | −0.01 (0.01) |
| Obesity (BMI) | ||||
| ≤25 kg/m2 | 63 | −0.03 (0.58) | ||
| >25 kg/m2 | 63 | −0.15 (0.61) | 0.28 | −0.12 (0.01) |
| Alcohol use | ||||
| <30 g/day | 85 | −0.029 (0.65) | ||
| ≥30 g/day | 16 | −0.102 (0.53) | 0.67 | −0.07 (0.03) |
| Fibrosis (Metavir score) | ||||
| F1 | 39 | −0.06 (0.59) | ||
| ≥F2 | 92 | −0.15 (0.60) | 0.06 | −0.21 (0.01) |
| IFNL3 genotype | ||||
| CC | 38 | 0.08 (0.59) | ||
| CT/TT | 80 | −0.246 (0.63) | 0.01 | 0.33 (0.01) |
| Viral genotype | ||||
| HCV genotype 1 | 80 | −0.145 (0.64) | ||
| Other subtypes | 53 | −0.017 (0.59) | 0.25 | −0.13 (0.01) |
a
The Student t test was used to test the lack of statistically significant differences for miR-122 log expression between categories of each variable investigated. The P value for each variable is reported. We also report the observed mean difference with the associated standard error.