FIG 1.

Decline in microRNA expression and diversity in the gut mucosa during chronic SIV infection. (A) MicroRNAs were isolated from intestinal tissue of chronically SIV-infected rhesus macaques (n = 3; red bars) and a SIV-negative healthy control (n = 1; green bars), sequenced, quantitated, and aligned to macaque miRNA records in miRBase using BLAST. (B) Bar graphs depict the number of miRNA sequences mapping to the macaque genome in each sample. (C) The total number of successfully mapped miRNA that were altered by at least 1.5-fold during chronic SIV infection is shown.