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ISGylation delays MHV-3 replication. Increased ISGylation coincides with prolonged survival and delayed N protein accumulation. USP18+/+ or USP18−/− mice were infected with 50 PFU MHV-3/mouse. Mice (n = 4) from each group were sacrificed daily, and livers were harvested for WB analysis. N protein and ISG15 conjugates were visualized by WB.
