FIG 7.

Comparison of Neu5Gc binding sites. Recognition of Neu5Gc by HPyV9 VP1 (A), Shiga-toxigenic E. coli SubB (PDB accession number 3DWP) (B), and porcine rotavirus strain CRW-8 VP8 (PDB accession number 3TAY) (C). The proteins are shown in surface representation. Neu5Gc is shown as in Fig. 4B. The critical amino acids making hydrogen bonds (black dashed lines) with Neu5Gc are shown in stick representation, and associated C-α atoms are shown as spheres. The water molecule in panel C is shown as a red sphere. The extra hydroxyl group of Neu5Gc makes two hydrogen bonds in each case.