TABLE 3.
Variable residues in the sialyloligosaccharide binding pocket of HPyV9 and LPyV VP1
| Loop | HPyV9 VP1 |
LPyV VP1 |
||
|---|---|---|---|---|
| Amino acid | Interaction | Amino acid | Interaction | |
| BC1 | E64 | Water-mediated H bond with O-7 of glycerol chain | D61 | None |
| D71 | Direct H bond with O-9 of glycerol chain | S68 | None | |
| D71 | Water-mediated H bond with O-8 of glycerol chain | S68 | None | |
| HI | S280 | Water-mediated H bond with O-8 of glycerol chain | T277 | Water-mediated H bond with O-8 of glycerol chain |
| N282 | Hydrophobic interaction with methyl moiety of N-acetyl group | V279 | Hydrophobic interaction with methyl moiety of N-acetyl group | |
| N282 | Direct H bond with extra hydroxyl of N-glycolyl group | V279 | None | |
| BC2cw | S76 | None | F73 | Hydrophobic interaction with methyl moiety of N-acetyl group of NAG |