Table 1.

Effect of nomifensine pretreatment on methamphetamine-induced stereotypy and persistent locomotion in mice.

	Expression pattern of behavior after drug challenge (No. of 30-s bins for 1 h)
	Head-bobbing	Circling	Sniffing	Biting	Persistent locomotion
Challenge: saline
Saline pretreatment	N.D.	0.1 ± 0.1	0.9 ± 0.6	2.4 ± 2.0	0.1 ± 0.1
Nomifensine pretreatment	N.D.	N.D.	3.8 ± 1.6	1.1 ± 0.6	1.5 ± 1.4
Challenge: 5 mg/kg METH
Saline pretreatment	1.4 ± 0.5	2.1 ± 1.4	18.5 ± 2.4††	N.D.	85.1 ± 3.5†††
Nomifensine pretreatment	5.6 ± 0.6***,†††	11.9 ± 1.1***,†††	36.4 ± 3.0***,†††	7.3 ± 0.9***	45.3 ± 2.6***,†††
Challenge: 10 mg/kg METH
Saline pretreatment	1.8 ± 0.9	1.5 ± 0.8	11.1 ± 5.4†	76.0 ± 9.6†††,‡‡‡	13.8 ± 1.6†††,‡‡‡
Nomifensine pretreatment	1.6 ± 0.8‡‡‡	1.8 ± 0.6‡‡‡	13.0 ± 5.2‡‡‡	75.6 ± 8.9†††,‡‡‡	14.6 ± 2.4†††,‡‡‡

Mice were pretreated with 3 mg/kg of nomifensine or saline for 30 min followed by challenge of methamphetamine (5 or 10 mg/kg) or saline for 1 h. Values are expressed as no. of 30-s bins for 1 h (mean ± SEM, n = 8). METH, methamphetamine; N.D., not detected.

^***P < 0.001, compared with corresponding group pretreated with saline (one-way ANOVA followed by a post-hoc Fischer's PLSD test).

^†P < 0.05

^††P < 0.01

^†††P < 0.001, compared with corresponding group challenged with saline (one-way ANOVA followed by a post-hoc Fischer's PLSD test).

^‡‡‡P < 0.001, compared with corresponding group challenged with 5 mg/kg METH (one-way ANOVA followed by a post-hoc Fischer's PLSD test).