Table 2.

Effect of PTIQ pretreatment on methamphetamine-induced stereotypy and persistent locomotion in mice.

	Expression pattern of behavior after drug challenge (No. of 30-s bins for 1 h)
	Head-bobbing	Circling	Sniffing	Biting	Persistent locomotion
Challenge: saline
Saline pretreatment	N.D.	N.D.	0.8 ± 0.5	2.3 ± 1.7	4.1 ± 2.7
PTIQ pretreatment	N.D.	N.D.	10.9 ± 3.7*	18.9 ± 4.2***	0.6 ± 0.4
Challenge: 5 mg/kg METH
Saline pretreatment	1.5 ± 0.2	0.9 ± 0.3	25.5 ± 1.6†††	N.D.	76.3 ± 1.6†††
PTIQ pretreatment	4.6 ± 0.6*,††	8.6 ± 1.7***,†††	36.4 ± 6.2†	12.5 ± 1.2***	28.5 ± 5.2***,†††
Challenge: 10 mg/kg METH
Saline pretreatment	2.3 ± 1.4	4.5 ± 4.4	7.3 ± 3.6‡‡‡	75.4 ± 11.1†††,‡‡‡	13.9 ±2.4†††,‡‡‡
PTIQ pretreatment	2.0 ± 1.1	2.4 ± 1.5‡‡	9.6 ± 4.0‡‡‡	73.9 ± 11.1†††,‡‡‡	15.0 ± 6.4†

Mice were pretreated with 10 mg/kg of PTIQ or saline for 30 min followed by challenge of methamphetamine (5 or 10 mg/kg) or saline for 1 h. Values are expressed as no. of 30-s bins for 1 h (mean ± SEM, n = 8). METH, methamphetamine; N.D., not detected; PTIQ, 4-phenyl-1,2,3,4-tetrahydroisoquinoline.

^***P < 0.001, compared with corresponding group pretreated with saline (one-way ANOVA followed by a post-hoc Fischer's PLSD test).

^†P < 0.05

^††P < 0.01

^†††P < 0.001, compared with corresponding group challenged with saline (one-way ANOVA followed by a post-hoc Fischer's PLSD test).

‡ P < 0.05

^‡‡P < 0.01

^‡‡‡P < 0.001, compared with corresponding group challenged with 5 mg/kg METH (one-way ANOVA followed by a post-hoc Fischer's PLSD test).