Table 4.

All the grade ≥3 AEs (counted in numbers)

AEs	Statistics from individual study (number of patients who experienced this AE)															TOTAL
	1*	2	3	4	5	6	7	8	9	10	11	12	13	14	15	Reporting Studies	Number	Incidence
Number of patients	35	53	42	46	42	29	80	18	21	19	47	115	114	64	47		772
Fatigue		1	2	1	1			4	2			6	19	1	1	10	38	4.9
Thrombocytopenia		8	3		1					4	2	8		1		7	27	3.5
Neutropenia			4							16	2					3	22	2.8
Hyperglycaemia		4	2	1	1		1		1			3	6	1	1	10	21	2.7
Anaemia										2	4	9	2	1	1	6	19	2.5
Pain						1	1					17				3	19	2.5
Nausea and vomiting			1			1			3	1		1	8			6	15	1.9
Diarrhoea		1			1				1	1		2	7			6	13	1.7
Elevated AST/ALT	3		2			2					2	3			1	6	13	1.7
Decreased appetite			1							2		1	7	1		5	12	1.6
Skin reaction								3					8			2	11	1.4
Dyspnoea												2	6			2	8	1.0
Deep venous thrombosis						1							5			2	6	0.8
Hypophosphataemia									2		1	1				3	4	0.5
Muco/tomatitis			2										2			2	4	0.5
Constipation												4				1	4	0.5
Potassium decreased												4				1	4	0.5
Leukocytes										4						1	4	0.5
Dehydration											1		2			2	3	0.4
Hyperuricaemia						1				2						2	3	0.4
Elevated ALK phosphatase	1											2				2	3	0.4
Hyponatraemia										3						1	3	0.4
Musculoskeletal pain		1										1				2	2	0.3
Elevated γGT					1	1										2	2	0.3
Cough												2				1	2	0.3
Dyspepsia													2			1	2	0.3
Bilirubin elevation												2				1	2	0.3

^*Study number.