Table 6.

The differences in AE-incidences in the two age groups

Median (range) age (years)	Lower age group incidence	Number of AEs	Higher age group incidences	Number of AEs	X2	P
	23 (4–78)		58 (18–84)
Hyperglycaemia	16.8	32	14.5	84	0.5935	0.4411
Nausea and vomiting	21.5	41	16.0	93	2.9864	0.0840
Fatigue	26.7	51	29.6	172	0.5895	0.4426
Anorexia	15.2	29	11.4	66	1.9473	0.1629
Diarrhoea	14.1	27	19.8	115	3.0649	0.0800
Skin reaction	6.8	13	23.9	139	26.6377	0.0000
Anaemia	15.7	30	7.9	46	9.8269	0.0017
Thrombocytopenia	8.4	16	11.9	69	1.7963	0.1802
Musculoskeletal pain	16.2	31	4.6	27	27.7561	0.0000
Elevated AST/ALT	12.6	24	6.0	35	8.7140	0.0032
Pain	30.9	59	1.5	9	154.0618	0.0000
Muco/stomatitis	0.5	1	15.8	92	31.8048	0.0000
Headache	15.7	30	1.4	8	63.0713	0.0000
Weight decreased	9.4	18	1.0	6	33.6032	0.0000
Neutropenia	5.8	11	5.0	29	0.1725	0.6779
Muscle spasm	1.0	2	3.8	22	3.5813	0.0584
Dehydration	1.0	2	2.6	15	0.9401	0.3322
Pyrexia	11.5	22	1.5	9	37.0658	0.0000
Constipation	11.0	21	3.3	19	17.4583	0.0000
Hypophosphataemia	5.2	10	0.7	4	14.2358	0.0002
Muscular weakness	3.1	6	1.2	7	2.1914	0.1388
Dyspnoea	9.4	18	1.5	9	26.4126	0.0000
Hypertriglyceridaemia	0.5	1	7.1	41	11.9265	0.0006
Elevated ALK phoshatase	6.3	12	0.3	2	25.2321	0.0000
Leukopenia	1.0	2	4.1	24	4.2001	0.0404
Creatinine elevation	3.7	7	1.5	9	2.2139	0.1368
Hypercholesterolaemia	0.0	0	5.0	29	9.9057	0.0016
Cough	7.9	15	3.1	18	7.9437	0.0048
Dyspepsia	0.0	0	2.1	12	2.7711	0.0960
Neuropathy	0.0	0	2.8	16	4.1000	0.0429
Paronychia	0.0	0	2.1	12	2.7711	0.0960