Table 5.
Parameter | Comparison | Geometric least-square mean ratio (%) | 90% CI (%) |
---|---|---|---|
AUCinf (nm h) | Mild vs. healthy (mild-matched) | 105 | (83.6, 132) |
Moderate vs. healthy (moderate-matched) | 119 | (94.1, 151) | |
Cmax (nm) | Mild vs. healthy (mild-matched) | 97.8 | (78.5, 122) |
Moderate vs. healthy (moderate-matched) | 114 | (91.1, 142) |
Abbreviations are as follows: AUCinf, area under the plasma concentration–time curve from time 0 to infinity; CI, confidence interval; and Cmax, maximal concentration.