Table 1.

Characteristics of patients with severe renal impairment, moderate renal impairment and normal renal function

Characteristic	Global population (n = 48)	Subdivision group as function of glomerular rate filtration
		Severe renal impairment (n = 10)	Moderate renal impairment (n = 28)	Normal renal function (n = 10)	Statistical test
GFRa (ml.min−1)	48.36 ± 24.19 [10.77–131.50]	21.83 ± 5.79†‡ [10.77–29.91]	43.89 ± 8.26*‡ [30.21–59.84]	85.20 ± 23.19*† [64.34–131.50]	c
Age (years)b	83 ± 8 [65–99]	86 ± 8 [76–99]	83 ± 7 [72–97]	78 ± 7 [65–89]	c
Weight (kg)b	63 ± 13 [40–100]	59 ± 9 [45–75]	61 ± 13 [40–90]	71 ± 13 [60–100]	c
Height (cm)b	161 ± 7 [144–183]	164 ± 3 [160–169]	160 ± 9 [144–183]	164 ± 7 [155–177]	c
Body mass index (kg m−2)b	23.9 ± 4.7 [15.6–39.1]	21.9 ± 2.6 [17.6–26.3]	23.8 ± 4.8 [15.6–36.3]	26.3 ± 5.3 [20.5–39.1]	c
Haemoglobin (g (100 ml)−1)b	125.3 ± 18.7 [90.0–157.0]	116.6 ± 23.4 [94.0–156.0]	127.5 ± 16.8 [90.0–154.0]	128.2 ± 19.4 [106.0–157.0]	c
Fibrinogen (g l−1)b	4.2 ± 1.2 [2.0–6.8]	3.8 ± 1.5 [2.0–5.9]	3.9 ± 1.1 [2.3–6.8]	4.9 ± 0.7 [4.7–6.4]	c
Sex ratio (male to female)	0.45	0.66	0.40	0.43	d

^aGlomerular filtration rate (GFR) estimated with Cockroft–Gault formula;

^bmean ± SD [range];

^ccomparison between groups using one-way ANOVA followed with Tukey's multiple comparison test (P < 0.05); and

^dcomparison between groups using χ² test.

^*P < 0.05, compared with severe renal impairment;

^†P < 0.05, compared with moderate renal impairment;

^‡P < 0.05, compared with normal renal function.