. 2013 Nov 20;77(6):1027–1038. doi: 10.1111/bcp.12291

Table 3.

Association between pharmacokinetic parameters and pharmacological effect of nefopam analysed by logistic regression

			Logistic regression					Overall correct percentage of prediction^*				Receiver operating curve analysis
			Model acceptance		Goodness of fit			OR and adjusted OR^‡
	Predictors	Unit increment	Final −2 log likelihood	P value of OTMC	Nagelkerke r²	Hosmer–Lemeshow test	Wald test	Exp (B)	Lower 95% CI	Upper 95% CI		Area under curves	P value^†	Cut value^*	Final model status
Tachycardia	AUC_nef0→∞	1 μg l⁻¹ h	26.390	0.128	0.250	0.867	0.049	1.001^‡	1.000	1.002	80%	0.788	0.019	3280 μg l⁻¹ h
	C_maxnef	1 μg l⁻¹	24.338	0.05	0.330	0.770	0.025	1.010^‡	1.003	1.018	83%	0.887	0.002	389 μg l⁻¹	Appropriate
		50 μg l⁻¹					0.025	1.580^‡	1.060	2.355					Appropriate
	RC_maxnef	1 μg l⁻¹ h⁻¹	24.058	0.046	0.341	0.755	0.023	1.005^‡	1.001	1.009	83%	0.892	0.001	764 μg l⁻¹ h⁻¹	Appropriate
		50 μg l⁻¹ h⁻¹					0.023	1.261^‡	1.033	1.538					Appropriate
PONV	AUC_nef0→∞	1 μg l⁻¹ h	28.742	0.079	0.328	0.550	0.021	1.002^‡	1.000	1.003	82.4%	0.726	0.056	3280 μg l⁻¹ h
	C_maxnef	1 μg l⁻¹	23.335	0.008	0.501	0.829	0.012	1.014^‡	1.003	1.026	85.3%	0.774	0.021	437.44 μg l⁻¹	Appropriate
		50 μg l⁻¹					0.012	2.053^‡	1.169	3.605					Appropriate
	RC_maxnef	1 μg l⁻¹ h⁻¹	23.482	0.009	0.497	0.882	0.012	1.007^‡	1.002	1.012	85.3%	0.744	0.21	859 μg l⁻¹ h⁻¹	Appropriate
		50 μg l⁻¹ h⁻¹					0.012	1.416^‡	1.078	1.859					Appropriate
Morphine requirement	AUC_nef0→∞	1 μg l⁻¹ h	41.468	0.006	0.253	0.350	0.023	0.988	0.987	1.000	68%	0.745	0.013	947 μg l⁻¹ h	Appropriate
	C_maxnef	1 μg l⁻¹	41.797	0.007	0.243	0.349	0.048	0.988	0.977	1.000	68%	0.724	0.024	79 μg l⁻¹	Appropriate
	RC_maxnef	1 μg l⁻¹ h⁻¹	41.567	0.006	0.250	0.353	0.047	0.994	0.988	1.000	68%	0.730	0.020	154 μg l⁻¹ h⁻¹	Appropriate

Abbreviations are as follows: AUC_nef0→∞, Area Under Curve of time course of nefopam plasma concentration; C_maxnef, nefopam plasma maximum concentration; CI, confidence interval; OR, odds ratio; OTMC, omnibus test of model coefficients; PONV, postoperative nausea and vomiting; RC_max, rate of increase of plasma concentration.

The cut value corresponds to the predicted probability of the model higher than 0.60 for tachycardia, 0.80 for PONV and 0.50 for morphine requirement.

^†

Null hypothesis/true area = 0.5.

^‡

Adjusted for confounding covariates (see the results of the pharmacodynamics assessment); AUC_nef0→∞, C_maxnef and RC_maxnef were ranged, respectively, within 382.5–3620 μg l⁻¹ h, 19.2–512.8 μg l⁻¹ and 37.7–1037 μg l⁻¹ h⁻¹.