Figure 1.

Whole blood or plasma concentrations (means ± SD) of voclosporin (VCS) 0.4 mg kg⁻¹ every 12 h (Q12H) alone and with ketoconazole 400 mg once daily (QD; A); VCS 0.4 mg kg⁻¹ alone and following 10 days of rifampin 600 mg QD (B); midazolam 7.5 mg alone and with VCS 0.4 mg kg⁻¹ Q12H (C1); α-hydroxy-midazolam after administration of midazolam 7.5 mg alone and with VCS 0.4 mg kg⁻¹ Q12H (C2); VCS 0.4 mg kg⁻¹ Q12H alone and with verapamil 80 mg every 8 h (D); and digoxin 0.25 mg QD alone and with VCS 0.4 mg kg⁻¹ Q12H (E). (A) , VCS alone; , VCS + ketoconazole. (B) , VCS alone; , VCS + rifampin. (C1) , midazolam alone; , midazolam + VCS. (C2) , midazolam alone; , midazolam + VCS. (D) , VCS alone; , VCS + verapamil. (E) , digoxin alone; , digoxin + VCS